Nicht reproduzierbare Krebsforschung

Den Versuch, psychologische Studien zu reproduzieren, hatten wir hier kürzlich schon einmal. Nun wurde in der Nature eine Studie veröffentlicht, in der 53 landmark studies aus der Onkologie und Hämatologie untersucht werden. Ergebnis:

It was acknowledged from the outset that some of the data might not hold up, because papers were deliberately selected that described something completely new, such as fresh approaches to targeting cancers or alternative clinical uses for existing therapeutics. Nevertheless, scientific findings were confirmed in only 6 (11%) cases. Even knowing the limitations of preclinical research, this was a shocking result.

“Shocking” trifft es ganz gut.

Begley, C. Glenn; Ellis, Lee M. (2012): Drug development: Raise standards for preclinical cancer research. In: Nature 483 (7391), S. 531–533.